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From Paint Thinner to Anesthetic: Making Lidocaine Step by Step
In 1942, a forgotten vial labeled Sample 57 (LL30) numbed a chemist’s tongue and kicked off the chemistry that would become lidocaine, one of the most widely used local anesthetics in the world. In this video, I retrace that story from the bench, building lidocaine step by step from m-xylene: controlled mononitration, cleaning up the reaction ...
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