The 'Learn to Code' era is over — as an AI editor, here's the 'Intent Architecture' roadmap I’m giving my kids instead

Coding is becoming a background task. Discover why the "syntax barrier" has vanished and the three orchestration skills I’m ...

The 50 best movies on HBO Max for dedicated cinephiles

Almost 100 years of cinema are represented on this list: starting with City Lights (1931) and extending all the way to 2026 ...
eLife

Molidustat Targets a Synthetic Lethal Vulnerability in APC-Mutant Colorectal Cancer through GSTP1 and PHD2 Co-Inhibition

This important paper substantially advances our understanding of how Molidustat may work, beyond its canonical role, by identifying its therapeutic targets in cancer. This study presents a compelling ...
eLife

Serotonergic modulation of motor subspace dynamics drives a sleep-independent quiescent state

The dorsal raphe nucleus (DRN) serotonergic (5-HT) system has been implicated in regulating sleep and motor control; however, its specific role remains controversial. In this study, we found that ...

The 'learn to code' era is officially over: Why I switched my kids to 'intent architecture' instead

As AI agents move from writing snippets to building entire systems, the $100k skill of the last decade is becoming a ...
AHA/ASA Journals

Targeting Interleukin-8–Mediated Cellular Crosstalk Reverses Hypertrophic Cardiomyopathy and Cardiac Fibrosis in Noonan Syndrome

BACKGROUND: Genetic variants in components or regulators of the RAS-MAPK signaling pathway are causative for severe and early-onset hypertrophic cardiomyopathy (HCM) in patients with Noonan syndrome ...