Background and Objective: Narcotic analgesics such as hydromorphone undergo an extensive first-pass effect resulting in a low systemic bioavailability following oral administration. Alternative dosing ...

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Industry is adapting to the increasing complexity and poor solubility and bioavailability of molecules in the pipeline. Poor solubility and low bioavailability have hindered the development pipeline ...

During early germination, water uptake activates metabolic pathways that stimulate the production of hydrolytic enzymes like ...

When it comes to supplements, absorption matters just as much as the dosage. You could be taking the most potent multivitamin or mineral supplement, but if your body can’t absorb it properly, it won’t ...

Objective: Flavanones are polyphenols specific of citrus fruits, where they are present in high amounts. Although citrus fruits and juices are widely consumed in the world, little information has been ...

MELBOURNE, Australia, Nov. 24, 2025 (GLOBE NEWSWIRE) -- Gelteq Limited (“Gelteq” or the “Company”), a clinical and science-based company specialising in gel-based oral delivery solutions, today ...

Purpose: The effect of omeprazole on the oral bioavailability and urinary exposure of the Depomed formulation of extended-release(ER) ciprofloxacin was studied. Methods: A two-way crossover study was ...

Model-based formulation and technology selection methodologies facilitate rapid product development. A large percentage of new chemical entities (NCEs) have physicochemical properties that require ...