Blood stem cells develop through different stages to become fully mature red blood cells. This fundamental biologic process is defined by a series of complex metabolic processes, which are often ...

Glutamine serves as a pivotal nutrient in cancer cell metabolism, supplying both carbon and nitrogen required for biosynthetic and bioenergetic processes. Tumour cells often exhibit ‘glutamine ...

Glutamine serves as a central nutrient in both cancer cells and immune cells within the tumour microenvironment, supporting biosynthesis, energy production and redox balance. Tumour cells frequently ...

A new review article highlights the expanding importance of glutamine metabolism in shaping the tumor microenvironment, offering fresh perspectives on how metabolic interactions influence cancer progr ...

How glutamine affects BATF2 and cancer cells Many cancers are resistant to treatments that trigger the STING pathway. More recently, studies have shown that epigenetic changes—which turn genes on and ...

Losing muscle strength is a natural part of aging. At the core of this decline is a drop in the number of muscle stem cells (MuSCs), the specialized cells responsible for maintaining and regenerating ...

Figure 1 BET inhibition is synthetic lethal to OXPHOS blockage in liver cancer. Left: GDH1-dependent glutamine metabolic remodeling upon BET inhibition. Right: “Synthetic lethality” targeting OXPHOS ...

A new wave of scientific interest is spotlighting GOT2—glutamic-oxaloacetic transaminase 2—as a compelling therapeutic target in the fight against pancreatic cancer, one of the most lethal and ...

Co-corresponding authors Jian Xu,PhD, (left) and Min Ni, PhD, (right) and co-first authors Junhua Lyu, PhD, (center left) and Yuannyu Zhang, PhD, (center right) identified and characterized a ...