Chimeric antigen receptor-T cell (CAR-T cell) therapies have been a significant advance in the field of cancer immunotherapeutics in recent years, particularly for B-cell malignancies. Yet, this ...

Magnetic resonance imaging (MRI) has become integral to the non-invasive evaluation of bone marrow, offering both anatomical and functional insights into marrow composition and pathology. Conventional ...

Bone marrow adiposity refers to the presence and behaviour of fat cells within the marrow cavity, a compartment traditionally associated with blood production and bone turnover. Far from being inert, ...

In multiple myeloma, abnormal plasma cells build up inside bone marrow -- the spongy tissue inside large bones where blood cells are produced. Over time, myeloma cells cause damage to bones, kidneys, ...

Researchers discovered that chronic inflammation fundamentally remodels the bone marrow, allowing mutated stem cell clones to quietly gain dominance with age. Reprogrammed stromal cells and interferon ...

Myeloblasts are a type of immature white blood cell that form inside the bone marrow. Abnormal numbers of them can indicate serious health conditions. White blood cells are part of the immune system, ...